亚洲社会药学
亚洲社会药学

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›› 2014, Vol. 9 ›› Issue (2): 47-50.doi:

• 论文 •    下一篇

Analysis of Influential Factors on the Efficacy of Itraconazole Injection forTreating Fungal Infections in Hematologic Malignancies Patients

DONG Wei-hua1, 2, HUANG Tai-kang1, 3, DONG Ya-lin2, ZHOU Yang2   

  1. 1. Research Center for Social Pharmacy, Shenyang Pharmaceutical University, Shenyang 100016, China;2. The First Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an 710061, China;3. China Food and Drug Administration, Beijing 100810, China
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-06-20 发布日期:2014-06-20
  • 通讯作者: DONG Wei-hua

Analysis of Influential Factors on the Efficacy of Itraconazole Injection forTreating Fungal Infections in Hematologic Malignancies Patients

DONG Wei-hua1, 2, HUANG Tai-kang1, 3, DONG Ya-lin2, ZHOU Yang2   

  1. 1. Research Center for Social Pharmacy, Shenyang Pharmaceutical University, Shenyang 100016, China;2. The First Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an 710061, China;3. China Food and Drug Administration, Beijing 100810, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2014-06-20 Published:2014-06-20
  • Contact: DONG Wei-hua

摘要： Objective To analyze the influential factors on the efficacy of itraconazole injection in the treatment of fungal infections for
hematologic malignancies patients. Methods 85 hematologic malignancy patients with fungal infections were selected to treat with
itraconazole injection. Multiple logistic regression was used to analyze 27 factors that probably affect the efficacy of itraconazole
injection, these factors including four aspects: basic situation of the patients, use of itraconazole injection, combined drugs use, and
laboratory indicators before and after treatment. Results and Conclusion Four factors such as the patient’s gender, the combination
of fluconazole, macrolides, and carbamazepine were eventually conducted into the regression equation and we found the factors that
reduce the efficacy of itraconazole injection were the combination use of fluconazole and carbamazepine.

关键词: itraconazole injection, logistic regression, hematologic malignancy, influential factor

Abstract: Objective To analyze the influential factors on the efficacy of itraconazole injection in the treatment of fungal infections for
hematologic malignancies patients. Methods 85 hematologic malignancy patients with fungal infections were selected to treat with
itraconazole injection. Multiple logistic regression was used to analyze 27 factors that probably affect the efficacy of itraconazole
injection, these factors including four aspects: basic situation of the patients, use of itraconazole injection, combined drugs use, and
laboratory indicators before and after treatment. Results and Conclusion Four factors such as the patient’s gender, the combination
of fluconazole, macrolides, and carbamazepine were eventually conducted into the regression equation and we found the factors that
reduce the efficacy of itraconazole injection were the combination use of fluconazole and carbamazepine.

Key words: itraconazole injection, logistic regression, hematologic malignancy, influential factor

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